tag:blogger.com,1999:blog-6820870938855079762024-02-07T20:33:34.548-08:00Biotechnology-2020Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.comBlogger9125tag:blogger.com,1999:blog-682087093885507976.post-82885412122448524852020-02-26T04:17:00.000-08:002020-02-26T04:17:28.404-08:00<div dir="ltr" style="text-align: left;" trbidi="on">
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<b><span style="color: #333333; font-family: "Times New Roman", serif;"><span style="font-size: x-large;">The glucose-lowering drug reduces obesity indices in
children and adolescents, study shows</span></span></b></h2>
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<span style="background: white; color: #333333; font-family: "Arial","sans-serif";">A new study has shown metformin - a glucose-lowering drug
commonly used to treat diabetes - to be effective at lowering some measures of
obesity in children and adolescents.</span></h3>
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<span style="background: white; color: #333333; font-family: "Arial","sans-serif";">The researchers searched the medical literature for
randomized clinical trials that examined the effects of metformin use on
obesity measures in children and adolescents. Overall, they found significant
reductions in body mass index (BMI), body weight, waist circumference, and fat
mass, but not in lean body mass. </span><span style="background: white; color: #333333; font-family: "Arial","sans-serif";">However, the reductions in BMI and waist
circumference was not significant in the youngsters who were overweight or
obese.</span></h3>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com1tag:blogger.com,1999:blog-682087093885507976.post-47133997288325905242019-08-08T02:37:00.000-07:002019-08-08T02:37:00.975-07:00Artificial enzymes perform reactions on living cells<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEge4wjU12Ynt4UZZFlqMp_ePDUhyphenhyphenL3eWr7FB4demH4Kd0Sh4avFFZeWO3RdM-AsfsQieWud1XZQxzigPPOUa2Fqvjn_gc8oMQ3adD8UxLuiyJIsw1uOiM82RzmUEdEwPxFOXdj_OHavNnU/s1600/stanfordscie.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="480" data-original-width="800" height="240" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEge4wjU12Ynt4UZZFlqMp_ePDUhyphenhyphenL3eWr7FB4demH4Kd0Sh4avFFZeWO3RdM-AsfsQieWud1XZQxzigPPOUa2Fqvjn_gc8oMQ3adD8UxLuiyJIsw1uOiM82RzmUEdEwPxFOXdj_OHavNnU/s400/stanfordscie.jpg" width="400" /></a></div>
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<span style="background-color: white; font-family: Times, "Times New Roman", serif; font-size: x-large; text-align: justify;"><span style="color: #999999;">Nature has evolved thousands of enzymes to facilitate the many chemical reactions that take place inside organisms to sustain life. Now, researchers have designed artificial enzymes that sit on the surfaces of living cells and drive reactions that could someday target drug therapies to specific organs.</span></span></h3>
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<span style="font-family: Times, "Times New Roman", serif; font-size: large;"><span style="color: #666666;">Metalloenzymes are a class of enzymes that contain a metal ion, such as zinc, iron or copper. The metal ion helps the enzyme speed up, or "catalyze," chemical reactions that would otherwise occur very slowly or not at all. Scientists would ultimately like to develop a method to produce therapeutic drugs only at the sites of specific cells or organs of the human body, which could reduce side effects, and enzymes could help them reach that goal. Researchers set their sights on engineering an artificial enzyme that could catalyze a useful reaction, called the Diels-Alder reaction, right on the surfaces of living cells. Chemists use this reaction to synthesize drugs, agrochemicals, and many other molecules.</span></span></div>
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<b style="mso-bidi-font-weight: normal;"><span style="background: rgb(255, 255, 255); font-family: "Times New Roman", serif; line-height: 115%;"><span style="color: #b45f06; font-size: x-large;">How do they work on it:</span></span></b></h3>
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<span style="font-family: Times, Times New Roman, serif; font-size: large;"><span style="color: #666666;"><span style="background: white; line-height: 115%;">To make their artificial enzyme, the researchers began with a protein called the A</span><sub style="-webkit-text-stroke-width: 0px; border-radius: 0px !important; bottom: -0.25em; box-sizing: border-box; font-variant-caps: normal; font-variant-ligatures: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; widows: 2; word-spacing: 0px;">2A</sub><span style="-webkit-text-stroke-width: 0px; float: none; font-variant-caps: normal; font-variant-ligatures: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; widows: 2; word-spacing: 0px;"> adenosine
receptor, which is naturally present on the surfaces of some cells in the body.
They modified a molecule that binds to this receptor with a copper-containing the chemical group that catalyzes the Diels-Alder reaction. When the researchers
placed the resulting compound in a culture dish containing living human cells,
it attached to the A</span><sub style="-webkit-text-stroke-width: 0px; border-radius: 0px !important; bottom: -0.25em; box-sizing: border-box; font-variant-caps: normal; font-variant-ligatures: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; widows: 2; word-spacing: 0px;">2A</sub><span style="-webkit-text-stroke-width: 0px; float: none; font-variant-caps: normal; font-variant-ligatures: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; widows: 2; word-spacing: 0px;"> adenosine receptors on the cells, forming an artificial
enzyme. This enzyme catalyzed the Diels-Alder reaction with an up to 50 percent
yield. The researchers say that in the future, artificial enzymes might be
designed that bind to proteins found only on specific cell types, for example,
cancer cells. Then, the enzyme could convert an inactive compound into a drug
to selectively kill those cells.</span></span><span style="line-height: 115%;"><o:p></o:p></span></span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-4526705366503915062019-07-23T03:59:00.000-07:002019-07-23T04:01:11.298-07:00Scientists recreate blood-brain barrier defect outside the body<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg1fBi-ecH0xZTHMHjT2dYArgodGLj3kmEE8g0394SyZ8047aDiynzdC7unvNrm9foOMigBU1cLE3Tpf-wZqysicFeEWV6IArT_ZTm5ZYOCLzxaf3cW7z50Lttg_3WUNuW82di6wSXL358/s1600/download+%25281%2529.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="159" data-original-width="316" height="200" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg1fBi-ecH0xZTHMHjT2dYArgodGLj3kmEE8g0394SyZ8047aDiynzdC7unvNrm9foOMigBU1cLE3Tpf-wZqysicFeEWV6IArT_ZTm5ZYOCLzxaf3cW7z50Lttg_3WUNuW82di6wSXL358/s400/download+%25281%2529.jpg" width="400" /></a></div>
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<span style="background-color: white; color: #45818e; font-family: "times new roman", serif; font-size: x-large; text-align: justify;">Scientists can't make a living copy of your brain outside your body.
That's the stuff of science fiction. But in a new study, they recreated a
critical brain component, the blood-brain barrier that functioned as it would
in the individual who provided the cells to make it. Their achievement provides
a new way to make discoveries about brain disorders and, potentially, predict
which drugs will work best for an individual patient.</span><br />
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<span style="font-family: "times new roman" , serif;"><span style="font-size: large;">What’s
the function of BBB?</span></span></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgqniK_eLb6dCICLH9yHKleUgqX6PIArskERfs6CmtQ2sm39uEocHN28D6PQbrB3T0WaLhXlHtQgUQSljaPBGKBKUCfxv6Pj7Rv9mRUsAv7XWY81HUqGVnqHvdMXXPKNVUfZPjGy8KY9NY/s1600/enhancedhuma.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="735" data-original-width="1400" height="210" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgqniK_eLb6dCICLH9yHKleUgqX6PIArskERfs6CmtQ2sm39uEocHN28D6PQbrB3T0WaLhXlHtQgUQSljaPBGKBKUCfxv6Pj7Rv9mRUsAv7XWY81HUqGVnqHvdMXXPKNVUfZPjGy8KY9NY/s400/enhancedhuma.jpg" width="400" /></a></div>
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<span style="background-color: white; font-family: "times new roman" , serif; font-size: large;">The blood-brain barrier acts as a gatekeeper by blocking toxins and
other foreign substances in the bloodstream from entering brain tissue and
damaging it. It also can prevent potential therapeutic drugs from reaching the
brain. Neurological disorders such as amyotrophic lateral sclerosis (Lou
Gehrig's disease), Parkinson's disease and Huntington's disease, which
collectively affects millions of people, have been linked to defective
blood-brain barriers that keep out biomolecules needed for healthy brain activity.</span></div>
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<span style="font-size: large;"><span style="background: white; font-family: "times new roman" , serif;">How it was generated:</span></span></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcozV03I3TsKrkGmkIKapTewZdc7V_i4BrL_tuA6la4rPwkB71TonOjyIBWNgMZXkH2ZSJGGwB5rUVz8hzdkrNCtkszMx9-6ZRu-fbc5r6djanzHZFg2EjbpO05wz3LIfj4GRGldfFyb8/s1600/shutterstock_506591185.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="735" data-original-width="1400" height="210" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgcozV03I3TsKrkGmkIKapTewZdc7V_i4BrL_tuA6la4rPwkB71TonOjyIBWNgMZXkH2ZSJGGwB5rUVz8hzdkrNCtkszMx9-6ZRu-fbc5r6djanzHZFg2EjbpO05wz3LIfj4GRGldfFyb8/s400/shutterstock_506591185.jpg" width="400" /></a></div>
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<span style="background-color: white; font-family: "times new roman" , serif; font-size: large;">For their
study, a team of investigators generated stem cells known as induced
pluripotent stem cells, which can produce any type of cell, using an individual
adult's blood samples. They used these special cells to make neurons,
blood-vessel linings, and support cells that together make up the blood-brain
barrier. The team then placed the various types of cells inside Organ-Chips,
which recreated the body's microenvironment with the natural physiology and
mechanical forces that cells experience within the human body.</span></div>
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<span style="font-family: "times new roman" , serif;"><span style="font-size: large;">The
living cells soon formed a functioning unit of a blood-brain barrier that
functions as it does in the body, including blocking entry of certain drugs.
Significantly, when this blood-brain barrier was derived from cells of patients
with Huntington's disease or Allan-Herndon-Dudley syndrome, a rare congenital neurological disorder, the barrier malfunctioned in the same way that it does
in patients with these diseases.</span><span style="font-size: 12pt;"><o:p></o:p></span></span></div>
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<span style="font-family: "times new roman" , serif;"><span style="font-size: large;">Well!!
This was not the first time:</span></span></h3>
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<span style="background-color: white; font-family: "times new roman" , serif; font-size: large; text-align: justify;"><br /></span></div>
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<span style="background-color: white; font-family: "times new roman" , serif; font-size: large; text-align: justify;">Scientists have created blood-brain barriers outside the body before,
this study further advanced the science by using induced pluripotent stem cells
to generate a functioning blood-brain barrier, inside an Organ-Chip, that
displayed a characteristic defect of the individual patient's disease.</span></div>
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<span style="font-size: large;"><span style="background: white; font-family: "times new roman" , serif;">The study's findings open a promising pathway for precision medicine</span><span style="font-family: "times new roman" , serif;">. The possibility of using a
patient-specific, multicellular model of a blood-brain barrier on a chip
represents a new standard for developing predictive, personalized medicine.</span></span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-19503239640765393382019-07-18T03:18:00.000-07:002019-07-18T03:18:34.160-07:00Eggshells can enhance the growth of new, strong bones<div dir="ltr" style="text-align: left;" trbidi="on">
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgtK6Q3JrpQ9vHpZGHWfTQZrV5M9TNVtXFplaAhRWjIy42Loh6hU2cV75gQ-pEUywPWVgPYMhe-yvWyxZl4mDQ47MJtewZLzkfrTriZ67JLlATUnlKuNm-a7t7XgPXG406xTVKOS0dWBKc/s1600/eggshell-bone-growth-2.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="900" data-original-width="1600" height="225" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgtK6Q3JrpQ9vHpZGHWfTQZrV5M9TNVtXFplaAhRWjIy42Loh6hU2cV75gQ-pEUywPWVgPYMhe-yvWyxZl4mDQ47MJtewZLzkfrTriZ67JLlATUnlKuNm-a7t7XgPXG406xTVKOS0dWBKc/s400/eggshell-bone-growth-2.jpg" width="400" /></a></div>
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<span style="color: #b45f06; font-size: x-large;"><span style="background: white; font-family: "Times New Roman", serif; line-height: 115%;">Eggshells can enhance
the growth of new, strong bones needed in medical procedures, a team of researchers has discovered.</span></span></h4>
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<span style="background-color: white; font-family: "Times New Roman", serif;"><span style="color: #666666; font-size: x-large;">Through the innovative process, crushed eggshells are inserted into a hydrogel mixture that
forms a miniature frame to grow bone in the laboratory to be used for bone
grafts. To do so, bone cells would be taken from the patient's body, introduced
into this substance and then cultivated in an incubator before the resulting
new bone is implanted into the patient.</span></span></div>
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<span style="background: white; font-family: "Times New Roman", serif; line-height: 115%;"><b><span style="color: purple; font-size: x-large;">How it works:</span></b></span></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEipgPypuTP9f-limxP7azQnByZbXvTJ3Kskx6BTyhT85XGK9L74nVmk5AyttRbHpYj26o96_qa8s6_SKQV-HzvwS_xP_H87Dkz5p3WTWjUhyDb9x0fzWlhFM47FuVuryPQZfV1Zx6cYWLw/s1600/1200px-Eggshell_001.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="900" data-original-width="1200" height="300" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEipgPypuTP9f-limxP7azQnByZbXvTJ3Kskx6BTyhT85XGK9L74nVmk5AyttRbHpYj26o96_qa8s6_SKQV-HzvwS_xP_H87Dkz5p3WTWjUhyDb9x0fzWlhFM47FuVuryPQZfV1Zx6cYWLw/s400/1200px-Eggshell_001.jpg" width="400" /></a></div>
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<span style="color: #666666; font-size: x-large;"><span style="background: white; font-family: "Times New Roman", serif; line-height: 115%;">The research
demonstrates that when eggshell particles - which are primarily made of calcium
carbonate - are incorporated into the hydrogel mixture, they increase bone
cells' ability to grow and harden, which could potentially result in faster
healing. And, because the bone would be generated from cells taken from the
patient, the possibility the individual's immune system would reject the new
material is greatly reduced</span>.</span></div>
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<span style="color: #666666; font-size: x-large;"><span style="background: white; font-family: "Times New Roman", serif; line-height: 115%;">The process could
also be used to help grow cartilage, teeth, and tendons</span>. <o:p></o:p><span style="background-color: white; font-family: "Times New Roman", serif;">One day, eggshell
particles could also serve as a vehicle to deliver proteins, peptides, growth
factors, genes and medications to the body.</span></span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-54866457068791096232019-06-25T00:06:00.000-07:002019-06-25T00:06:32.384-07:00Edible insects? Lab-grown meat? The real future food is lab-grown insect meat<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-family: Times, Times New Roman, serif; font-size: x-large;"><span style="background: white; font-weight: normal; line-height: 115%;">Livestock farming is destroying our planet. It is a major
cause of land and water degradation, biodiversity loss, acid rain, coral reef
degeneration, deforestation and of course, climate change. Plant-based
diets, insect farming, lab-grown meat, and genetically modified animals have all
been proposed as potential solutions. Which is best? All of these combined, say
researchers.</span></span></div>
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><strong><span style="background: white; line-height: 115%;">Alternatives to
conventional meat farming:</span></strong></span></h3>
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<span style="font-weight: normal;"><span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><span style="background: white; line-height: 115%;">Genetically modified livestock, for example, that produce less
methane or resist disease can do little to relieve issues like land and water
degradation, deforestation and biodiversity loss.</span> But for meat-lovers,
soy- or mushroom-based substitutes just don't hit the spot -- and some plant
crops are as thirsty as livestock.</span></span></div>
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<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><br /></span></div>
<span style="font-size: large;"><div style="text-align: justify;">
<span style="font-family: Arial, Helvetica, sans-serif;">Insect farming has a much lower water and space requirement, think vertical farming and twice as much of a cricket is edible than of a
big-boned, big-bellied cow. Unsurprisingly though, creepy crawlies are proving
even harder for consumers to swallow.</span></div>
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<span style="font-family: Arial, Helvetica, sans-serif;"><br /></span></div>
<span style="font-weight: normal;"><div style="text-align: justify;">
<span style="font-family: Arial, Helvetica, sans-serif;">Finally, lab-grown meat could
squeeze water and space savings furthest of all, without compromising on taste.
Culturing beef, pork or chicken cells might require even more energy and
resources than livestock farming</span></div>
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><strong>Lab-grown insect meat:</strong></span></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj9p7c3jeMNsH43Aj3kQRpK0kgFtgXm2IWhd_oI9_48UcerXtP0ng6hWme3M68_Z5q2gfDX8dTDgPepnmhSe-qDZSfTr-6kYquhuDHy9YZbN3Ub2NlqYzHDKr03kbkd8mkxQ-dn1NskJnc/s1600/meat-test-tube-lab-735-350.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="350" data-original-width="735" height="190" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj9p7c3jeMNsH43Aj3kQRpK0kgFtgXm2IWhd_oI9_48UcerXtP0ng6hWme3M68_Z5q2gfDX8dTDgPepnmhSe-qDZSfTr-6kYquhuDHy9YZbN3Ub2NlqYzHDKr03kbkd8mkxQ-dn1NskJnc/s400/meat-test-tube-lab-735-350.jpg" width="400" /></a></div>
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<span style="font-weight: normal;"><span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><span style="background: white; line-height: 115%;">Research for these applications has
led already to inexpensive, animal-free growth media for insect cells including soy and yeast-based formulas as well as successful 'suspension
culture'.</span></span></span></div>
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<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><br /></span></div>
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<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">Technology developed to stimulate the movement of insect tissue
for bio-robotics could also be applied to food production, since regular
contraction may be required for cultured insect muscle to develop a 'meaty'
texture. A particularly efficient method is optogenetic engineering, whereby
cells are made to contract in response to light by introducing a new gene --
another advantage of insect cells, which more readily accept genetically
modifications then do other animal cells.</span></div>
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><strong>How will
it tastes?</strong></span></h3>
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<span style="font-weight: normal;"><span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><span style="background: white; line-height: 115%;">So, future food production could be a sight to behold: silent
discos of insect muscles, flexing to the pulse of lasers in vast pools of soy
juice. But how will it taste?</span></span></span></div>
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<span style="background-color: white; font-family: Arial, Helvetica, sans-serif;">According to researchers, despite this immense potential,
cultured insect meat isn't ready for consumption. Research is ongoing to master
two key processes: controlling the development of insect cells into muscle and fat and combining these in 3D cultures with a meat-like texture. For the latter,
sponges made from chitosan a mushroom-derived fiber that is also present in
the invertebrate exoskeleton are a promising option.</span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-2718493160744975502019-06-21T00:29:00.001-07:002019-06-21T02:51:27.859-07:00Meditation and Yoga can 'reverse' DNA reactions which cause Stress<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="background-color: white; font-family: "arial" , "helvetica" , sans-serif; font-size: large;">Mind-body interventions (MBIs) such as meditation, yoga and Tai Chi don't simply relax us; they can 'reverse' the molecular reactions in our DNA which cause ill-health and depression, according to a study.</span></div>
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<span style="background-color: white; color: #bf9000; font-family: "georgia" , "times new roman" , serif; font-size: large;"><u>Reason of Stress</u>:</span></h4>
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<span style="background-color: white; font-family: "arial" , "helvetica" , sans-serif; font-size: large;">When a person is exposed to a stressful event, their sympathetic nervous system (SNS) -- the system responsible for the 'fight-or-flight' response -- is triggered, in turn increasing production of a molecule called nuclear factor kappa B (NF-kB) which regulates how our genes are expressed.</span></div>
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<span style="background-color: white; font-family: "arial" , "helvetica" , sans-serif; font-size: large;">NF-kB translates stress by activating genes to produce proteins called cytokines that cause inflammation at the cellular level -- a reaction that is useful as a short-lived fight-or-flight reaction, but if persistent leads to a higher risk of cancer, accelerated aging and psychiatric disorders like depression.</span></div>
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<span style="background-color: white; color: #bf9000; font-family: "georgia" , "times new roman" , serif;"><span style="font-size: large;"><u>How it works</u>:</span></span></h4>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4tnCTp45g7QVmEMWHSTE_BACUQLWQq_Mb4CJz4UE8fuzt75F4v260dcNJIyFV_dEZzsTFlg7iW7BH4EhBuxCJgZr2oOacihpOjqlXtCcSQIZ2ZLjbuG8yXm4FUiKLKvjTy59gGjHYDC8/s1600/stocksnap_d8sw90plfx.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="800" data-original-width="1200" height="213" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEg4tnCTp45g7QVmEMWHSTE_BACUQLWQq_Mb4CJz4UE8fuzt75F4v260dcNJIyFV_dEZzsTFlg7iW7BH4EhBuxCJgZr2oOacihpOjqlXtCcSQIZ2ZLjbuG8yXm4FUiKLKvjTy59gGjHYDC8/s320/stocksnap_d8sw90plfx.jpg" width="320" /></a></div>
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<span style="background-color: white; font-family: "arial" , "helvetica" , sans-serif; font-size: large;">According to the study, however, people who practice MBIs exhibit the opposite effect - namely a decrease in the production of NF-kB and cytokines, leading to a reversal of the pro-inflammatory gene expression pattern and a reduction in the risk of inflammation-related diseases and conditions.</span></div>
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<span style="background-color: white; font-family: "arial" , "helvetica" , sans-serif; font-size: large;">More needs to be done to understand these effects in greater depth, for example how they compare with other healthy interventions like exercise or nutrition. But this is an important foundation to build on to help future researchers explore the benefits of increasingly popular mind-body activities.</span></div>
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<span style="background-color: white; color: #bf9000; font-family: "arial" , "helvetica" , sans-serif; font-size: large;"><u>Tai Chi improving brain metabolism:</u></span></h4>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjbGd_BLPkZwbtJIoAOzH_L1KOverGB7D0yNJeS-q3U71jtM_cqsvK23MPyI6dF32jGHJTOLYAru5qyKRQXvbtsd1TMd2-sgIwZnmWod3CdQEb25_fkd8EnqFlhn_pKk8BnD20W1qsA_Vg/s1600/tai-chi-master-sifu-jensen-10000-victories.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="345" data-original-width="493" height="223" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjbGd_BLPkZwbtJIoAOzH_L1KOverGB7D0yNJeS-q3U71jtM_cqsvK23MPyI6dF32jGHJTOLYAru5qyKRQXvbtsd1TMd2-sgIwZnmWod3CdQEb25_fkd8EnqFlhn_pKk8BnD20W1qsA_Vg/s320/tai-chi-master-sifu-jensen-10000-victories.jpg" width="320" /></a></div>
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<span style="background-color: white; font-family: "arial" , "helvetica" , sans-serif; font-size: large;">A growing body of evidence consisting of morphological magnetic resonance imaging (MRI) and functional MRI data suggests that Tai Chi can induce beneficial neuroplasticity. As a result, recent literature suggests the use of Tai Chi to treat both physical and psychological disorders, including stroke, Parkinson's disease, traumatic brain injury, and depression.</span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-77088636245035931042019-06-11T23:35:00.002-07:002019-06-11T23:35:45.964-07:00The bacteria building your baby<div dir="ltr" style="text-align: left;" trbidi="on">
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<h2 style="background: white; margin-top: 0cm;">
<span style="color: #38761d;"><span style="font-size: x-large;">The bacteria building your baby: </span></span></h2>
<h2 style="background: white; margin-top: 0cm;">
<span style="color: #38761d;"><span style="font-family: "Times New Roman", serif; line-height: 27.6px;"><span style="font-size: large;">Exposure to influential bacteria begins before we are born, new evidence confirms</span></span></span></h2>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhafeDU5eOJtY4CYGrdtLdn5F-JxHaTeQ55QL2KNbhPvclpFu_tkgikyRRjmDVbQlL2jIPnzpmNXz6ZKbYwJbxnpFU6qnI9zptTF3-rqeJ2jjDjgQLXqKqKOGvsdmjyyHEP6kwaEuk-kFw/s1600/SebastianKaulitzki.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1080" data-original-width="1080" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhafeDU5eOJtY4CYGrdtLdn5F-JxHaTeQ55QL2KNbhPvclpFu_tkgikyRRjmDVbQlL2jIPnzpmNXz6ZKbYwJbxnpFU6qnI9zptTF3-rqeJ2jjDjgQLXqKqKOGvsdmjyyHEP6kwaEuk-kFw/s320/SebastianKaulitzki.jpg" width="320" /></a></div>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt;">Researchers
have laid to rest a longstanding controversy: Is the womb sterile? A new study
used uniquely rigorous contamination controls to confirm that exposure to
bacteria begins in the womb and could help to shape the developing fetal immune
system, gut, and brain.</span></div>
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<strong><span style="background: white;"><span style="color: #bf9000; font-size: large;">The not-so-sterile womb:</span></span></strong></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjogqMU-LIuo7BCeEav7739ibzGbeW2nCMg8CsS-BX4Z95_XVfdQHvtKef01dwNN2Pn0HqUe3JMxO7Jxq6C__U676psr6Kuyru-xrMYOmrqrQj6GXHs0t8h5rMlzyi8hh7GeGBAq3ejJXM/s1600/12421682_f520.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="371" data-original-width="520" height="227" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjogqMU-LIuo7BCeEav7739ibzGbeW2nCMg8CsS-BX4Z95_XVfdQHvtKef01dwNN2Pn0HqUe3JMxO7Jxq6C__U676psr6Kuyru-xrMYOmrqrQj6GXHs0t8h5rMlzyi8hh7GeGBAq3ejJXM/s320/12421682_f520.jpg" width="320" /></a></div>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt;">Over the last decade,
numerous studies have detected bacterial DNA in amniotic fluid and first-pass
meconium [baby's first poop], challenging the long-held assumption that the
womb is sterile</span></div>
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<span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-family: "Times New Roman", serif; font-size: 14pt;">It is important to conclusively
determine whether the healthy womb harbors bacteria say the researchers,
because this 'fetal microbiome' would likely have a significant impact on the
developing immune system, gut, and brain.</span><o:p></o:p></div>
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<strong><span style="background: white;"><span style="color: #bf9000; font-size: large;">The fetal microbiome:</span></span></strong></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiIr3g-KnL1Y4ZmnO8XgTRc2poGHTDNBTPbmHbjBFH5wpyVMGt8VhJO3nA8Q_WrhG1cYDyzhap-cYh-WYvhkwWHyQCCHasbyWDqE0l6pRt1l7X7qEv1aaT_Lu3hYoOOh6gE3AxqVrLnjeI/s1600/1_DRusS1Gb3cjR92sus64IwA.jpeg" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" data-original-height="1336" data-original-width="1600" height="265" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiIr3g-KnL1Y4ZmnO8XgTRc2poGHTDNBTPbmHbjBFH5wpyVMGt8VhJO3nA8Q_WrhG1cYDyzhap-cYh-WYvhkwWHyQCCHasbyWDqE0l6pRt1l7X7qEv1aaT_Lu3hYoOOh6gE3AxqVrLnjeI/s320/1_DRusS1Gb3cjR92sus64IwA.jpeg" width="320" /></a><span style="background-color: white; color: #333333; font-family: "Times New Roman", serif; font-size: 12pt; text-align: left;"></span></div>
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<span style="background-color: white; font-family: "Times New Roman", serif; font-size: 14pt;">Interestingly,
the meconium microbiome varied hugely between individual newborns. The amniotic
fluid microbiome, for the most part, contained typical skin bacteria, such as
Propionibacterium acnes and Staphylococcus species.</span></div>
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<strong><span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial;"><span style="color: #bf9000; font-size: large;">A developmental role:</span></span></strong></h3>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiwxFMgd7-7E9WDvkpm0GSOSnsJ_ircTacvnO-l3dIJABKMP6e1XIMF3ukGS1WGjcElk3weC2EQ8ZxrsmHsxXaY2g7zH2LEPBLUVOxksq6sIYZoaCRU8nqnbUfJKqoEznEcEg83BdDm-zk/s1600/pexels-photo-baby-large.jpeg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" data-original-height="853" data-original-width="1280" height="212" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiwxFMgd7-7E9WDvkpm0GSOSnsJ_ircTacvnO-l3dIJABKMP6e1XIMF3ukGS1WGjcElk3weC2EQ8ZxrsmHsxXaY2g7zH2LEPBLUVOxksq6sIYZoaCRU8nqnbUfJKqoEznEcEg83BdDm-zk/s320/pexels-photo-baby-large.jpeg" width="320" /></a></div>
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<span style="font-family: "Times New Roman", serif; font-size: 14pt;">But what
might these bacteria be doing in the womb?</span></div>
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<span style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; font-family: "Times New Roman", serif; font-size: 14pt;">None of
these women or their babies had any sign of infection. In fact, the fetal
microbiome may prove to be a beneficial regulator of early development.</span><o:p></o:p></div>
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have found that levels of important immune modulators in meconium and
inflammatory mediators in amniotic fluid varied according to the amount and
species of bacterial DNA present. This suggests that the fetal microbiome has
the potential to influence the developing fetal immune system.</span><span style="color: #004276; font-family: "Times New Roman","serif"; font-size: 14.0pt; mso-fareast-font-family: "Times New Roman"; mso-fareast-language: EN-IN; mso-font-kerning: 18.0pt;"><o:p></o:p></span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-31682901462611424002019-06-03T03:05:00.001-07:002019-06-03T21:33:16.704-07:00Transgenic fungus rapidly killed malaria mosquitoes in West African study<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="color: #666666; font-size: x-large;"><i><u>Transgenic fungus rapidly killed malaria mosquitoes in West African study</u></i></span></h2>
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A fungus - genetically enhanced to produce spider toxin - can rapidly kill huge numbers of the mosquitoes that spread malaria, a study suggests.<br />
Trials, which took place in Burkina Faso, showed mosquito populations collapsed by 99% within 45 days. The researchers say their aim is not to make the insects extinct but to help stop the spread of malaria. The disease, which is spread when female mosquitoes drink blood, kills more than 400,000 people per year.<br />
Worldwide, there are about 219 million cases of malaria each year.</div>
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<b>How it was done??</b></div>
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<b>1.</b> Conducting the study, researchers at the University of Maryland in the US - and the IRSS research institute in Burkina Faso - first identified a fungus called Metarhizium pingshaense<span style="border: 0px; font-family: inherit; font-stretch: inherit; font-variant: inherit; letter-spacing: inherit; line-height: 1.375; margin: 0px; padding: 0px; vertical-align: baseline;">,</span> which naturally infects the Anopheles mosquitoes that spread malaria.</div>
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<b>2.</b> The next stage was to enhance the fungus. "They're very malleable, you can genetically engineer them very easily," Prof Raymond St Leger, from the University of Maryland. <span style="background-color: white; font-family: "helmet" , "freesans" , "helvetica" , "arial" , sans-serif;">They turned to a toxin found in the venom of a species of funnel-web spider in Australia. </span>The genetic instructions for making the toxin were added to the fungus's own genetic code so it would start making the toxin once it was inside a mosquito.</div>
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Laboratory tests showed the genetically modified fungus could kill quicker, and that it took fewer fungal spores to do the job. </div>
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<b>3.</b> The next step was to test the fungus in as close to real-world conditions as possible. </div>
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A 6,500-sq-ft fake village - complete with plants, huts, water sources and food for the mosquitoes - was set up in Burkina Faso. It was surrounded by a double layer of mosquito netting to prevent anything from escaping. </div>
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The fungal spores were mixed with sesame oil and wiped on to black cotton sheets. The mosquitoes had to land on the sheets to be exposed to the deadly fungus. The researchers started the experiments with 1,500 mosquitoes. </div>
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Tests also showed the fungus was specific to these mosquitoes and did not affect other insects such as bees.</div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0tag:blogger.com,1999:blog-682087093885507976.post-75588478846479880352019-04-18T03:09:00.002-07:002019-07-04T23:24:32.807-07:0023rd World Congress on Biotechnology on November 14-15, 2019 at Amsterdam, Netherlands<div dir="ltr" style="text-align: left;" trbidi="on">
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<span style="font-size: large;"><span style="font-family: "times new roman" , serif;"><span style="font-weight: normal;">Conference Series is organizing a </span>"23</span><sup style="font-family: "times new roman", serif;">rd</sup><span style="font-family: "times new roman" , serif;">
World Congress on Biotechnology"<span style="font-weight: normal;"> on November 14-15, 2019 at Amsterdam,
Netherlands. The theme of the conference is </span>“Exploration of latest Applications
in the field of Biotechnology”<span style="font-weight: normal;">.</span></span></span></h2>
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<span style="box-sizing: border-box;"><span style="box-sizing: border-box; font-weight: 700;"><span style="color: #b45f06; font-size: large;">Why to attend???</span></span></span></h3>
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<span style="box-sizing: border-box;"><span style="font-size: large;">Biotechnology-2019<span style="font-weight: 400;"> Conference is a multidisciplinary program with broad participation with members from around the globe focused on learning about Biotechnology and its advances. This is your best opportunity to reach the largest assemblage of participants from the Biotechnology community that is from academia, research entities, medical groups, related associations, societies and also from government agencies, pharmaceutical, biomedical and medical device industries.</span></span></span></div>
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<span style="box-sizing: border-box;"><span style="box-sizing: border-box; font-weight: 700;"><span style="color: #b45f06; font-size: large;">Target Audience:</span></span></span></h3>
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<span style="box-sizing: border-box;"><span style="font-size: large;">The target of this conference is to gather the members from both industrial and academic fields as the audience which includes; CEOs, COOs, Directors, Vice Presidents, Co-directors, Biotechnologists, Managing Directors, Industry Safety Officers, Environmental & Plant Scientists, Doctorates, Professors, Post Doctorate Fellows, Dealers of Consumer Products/ Managers, Pharmaceutical Scientists, Students from the related fields.</span></span></div>
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Sessions/Tracks:</b></span></h3>
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<span style="font-size: large;"><span style="font-family: "times new roman" , "serif"; line-height: 115%;"><b>Track 1:</b></span><span style="font-family: "times new roman" , "serif"; line-height: 115%;">
</span><span style="background: white; font-family: "times new roman" , serif; line-height: 115%;">Pharmaceutical Biotechnology and Drug
Design</span></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 2:</b> Animal
biotechnology</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 3:</b> Industrial
biotechnology</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 4:</b> Plant and
agriculture biotechnology</span></div>
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<span style="background: white; font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 5:</b>
Nano-Biotechnology</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 6:</b> Stem Cell Biotechnology</span></div>
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<span style="background: white; font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track
7:</b> Environmental Biotechnology</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 8:</b> Biotechnology
Industries In The Market</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 9:</b> Microfluidics For
Biotechnology</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 10:</b> Food Biotechnology</span></div>
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<span style="font-family: "times new roman", serif;"><span style="font-size: large;"><b>Track 11:</b> Marine Biotechnology</span></span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large;"><b>Track 12:</b> Cancer Biotechnology</span></div>
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<span style="font-family: "times new roman" , "serif"; font-size: large; line-height: 115%;"><b>Track 13:</b> Techniques of Biotechnology<o:p></o:p></span></div>
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<span style="font-family: "times new roman", serif;"><span style="font-size: large;"><b>Track 14:</b> Protein Engineering</span></span></div>
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<span style="background-color: white; font-family: "times new roman", serif;"><span style="font-size: large;"><b>Track 15:</b> Recombinant DNA technology</span></span></div>
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<span style="background-color: white; font-family: "times new roman", serif;"><span style="font-size: large;"><b>Track 16:</b> Biosensors in biotechnology</span></span></div>
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<span style="background-color: white; font-family: "times new roman", serif;"><span style="font-size: large;"><b>Track 17:</b> Biodegradation and
recycling</span></span></div>
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<span style="font-family: "times new roman", serif;"><span style="font-size: large;"><b>Track 18:</b> Biochemistry and
Biophysics</span></span></div>
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Biotechnology-2019http://www.blogger.com/profile/02358080675154574702noreply@blogger.com0